基于缺手性晶格的自膨胀镁支架的变形行为

V.H. Carneiro , H. Puga
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引用次数: 16

摘要

目前支架植入术通常采用金属合金,并且是永久性的。这一事实给患者带来了多种长期风险,如再狭窄、晚期支架血栓形成等。减轻这些问题的一个可能的解决方案是使用聚合物或金属基生物可吸收支架,这些支架往往会因腐蚀而降解,并且在支架功能完成后完全消除。此外,还需要找到部署这些设备的新方法。实现这一目标的一个途径是设计支架,消除气球膨胀的必要性,并能够通过自身的变形机制进行自我膨胀,例如通过具有auxetic行为。本研究的目的是建立一种支架的模型,该支架由可生物降解的材料(AZ91D镁合金)组成,揭示了缺氧行为,以适应支架设计的两种最新趋势。研究表明,所定义的支架模型在拉伸时能够扩展(形变行为),并揭示了一种变形机制,这可能是一个有趣的进一步发展。综上所述,本研究中所显示的生物降解和消耗特性的结合可能是这些医疗设备发展的未来一步。
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Deformation behaviour of self-expanding magnesium stents based on auxetic chiral lattices

Current stenting solutions commonly employ metal alloys and are permanent. This fact has the consequence of diverse long term risks for the patients, e.g. Restenosis, late-term stent Thrombosis, etc. One possible solution to attenuate these problems is the use of polymer or metallic based bioabsorbable stents that tend to be degraded by corrosion and completely eliminated after their scaffolding duties are fulfilled. Additionally, there is a need to find new ways of deploying these devices. A route to fulfill this goal, can be the design of stents that eliminate the necessity of balloon expansion and are able to self-expand by their own deformation mechanism, for example by possessing auxetic behavior. The objective of this study is the modeling of a stent that reveals auxetic behavior and is composed by a biodegradable material (AZ91D Magnesium alloy), to embrace both recent tendencies on stenting designs. It is shown that the defined stent modeling is able to expand when stretched (auxetic behavior) and reveals a deformation mechanism that may be interesting for further development. In conclusion, the combination of both biodegradable and auxetic characteristics shown in this study may be a future step in the evolution of these medical devices.

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