姜黄素水凝胶治疗银屑病

Y. Gupta, Neeraj Kumar, A. Shukla, Vishal Rai
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摘要

牛皮癣是一种慢性炎症性皮肤病,影响着全世界数百万人。目前银屑病的治疗方法包括局部皮质类固醇、免疫调节剂和光疗,但这些治疗方法可能疗效有限或引起副作用。姜黄素是一种具有抗炎和抗氧化特性的天然化合物,已被证明有可能作为牛皮癣的替代治疗方法。然而,姜黄素的低溶解度和生物利用度限制了口服或局部给药的有效性。姜黄素水凝胶,姜黄素的局部配方,已开发,以解决这些限制。本文就姜黄素水凝胶在银屑病治疗中的应用研究现状进行综述。本文就姜黄素的药理作用、姜黄素水凝胶的制备方法、姜黄素水凝胶治疗银屑病的临床前和临床研究进行了综述。总的来说,现有证据表明姜黄素水凝胶可能是银屑病的一种有希望的替代治疗方法,具有减少炎症、促进伤口愈合和改善银屑病患者整体生活质量的潜在益处。为了充分阐明姜黄素水凝胶的作用机理,优化其配方和给药方式,使其发挥最大的功效,还需要进一步的研究。
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Treatment of Psoriasis with the Help of Curcumin Hydrogel
Psoriasis is a chronic inflammatory skin disorder that affects millions of people worldwide. Current treatments for psoriasis include topical corticosteroids, immunomodulators, and phototherapy, but these treatments may have limited efficacy or cause side effects. Curcumin, a natural compound with anti-inflammatory and antioxidant properties, has been shown to have potential as an alternative treatment for psoriasis. However, the low solubility and bioavailability of curcumin limit its effectiveness when administered orally or topically. Curcumin hydrogel, a topical formulation of curcumin, has been developed to address these limitations. In this review, we summarize the current research on the use of curcumin hydrogel in the treatment of psoriasis. We discuss the pharmacological properties of curcumin, the formulation of curcumin hydrogel, and the preclinical and clinical studies investigating the efficacy and safety of curcumin hydrogel in psoriasis. Overall, the available evidence suggests that curcumin hydrogel may be a promising alternative treatment for psoriasis, with potential benefits in reducing inflammation, promoting wound healing, and improving overall quality of life for psoriasis patients. Further research is needed to fully elucidate the mechanism of action of curcumin hydrogel and to optimize its formulation and delivery for maximum efficacy.
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