亚历山大·弗莱明(纪念他诞辰140周年)

O. Voloshyn, H. Humeniuk, I. B. Chen
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摘要

亚历山大·弗莱明是一位杰出的苏格兰科学家,诺贝尔奖获得者,也是发现青霉素的细菌学家。他出生在苏格兰小镇达威尔附近。他曾就读于圣玛丽医院医学院,并在伦敦大学获得硕士和学士学位。这位年轻科学家的研究始于传染病的病因学、诊断和疫苗治疗的研究,他很快就开始与一位才华横溢的军医阿尔姆罗斯·赖特(Almroth Wright)一起为细菌感染患者寻找治疗方案。第一次世界大战期间,a·赖特和o·弗莱明在皇家军事医疗服务部门工作,他们的研究表明,受伤后使用防腐剂并不能有效地消灭细菌病原体。战后,弗莱明发现了一种具有明显抗菌作用的酶——溶菌酶。这一发现促使他积极寻找抗菌药物。1928年,亚历山大·弗莱明发现了第一种抗生素——青霉素。他发现青霉素是一种有效的抗菌物质,能对化脓性球菌和白喉杆菌产生作用。青霉素在临床实践中的广泛应用挽救了数亿人的生命。关键词:青霉素,溶菌酶,抗生素,细菌感染。
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Alexander Fleming (to the 140th anniversary of his birth)
Alexander Fleming is a prominent Scottish scientist, Nobel laureate, and bacteriologist who discovered penicillin. He was born near the small town Darwell in Scotland. He studied at St. Mary’s Hospital Medical School and received his master’s and bachelor’s degrees from London University. The research of the young scientist began with the study of the etiology, diagnosis and vaccine therapy of infectious diseases, he soon began working on finding treatment options for patients with bacterial infections with a talented military doctor Almroth Wright. Working in the Royal Military Medical Service during the First World War, A. Wright and O. Fleming showed that the use of antiseptics after injury does not destroy bacterial pathogens effectively. After the war, O. Fleming made an extremely important discovery of a lytic enzyme with a pronounced antibacterial effect - lysozyme. This discovery prompted him to search for antibacterial drugs actively. In 1928, Alexander Fleming discovered the first antibiotic – penicillin. He found that penicillin is an effective antibacterial substance that can affect pyogenic cocci and diphtheria bacilli. The widespread introduction of penicillin into clinical practice has saved hundreds millions of lives. Keywords: penicillin, lysozyme, antibiotics, bacterial infections.
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