己酮可可碱在狭窄动脉血流中的应用

S. R. Shah, S. U. Siddiqui
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引用次数: 0

摘要

降低血液粘度的药物,如“己酮茶碱”,通过降低血液粘稠度来改善血液流动。糖尿病患者的血流阻力高于非糖尿病患者。因此,糖尿病患者的血流阻力越高,就越容易发生高血压。因此,糖尿病患者可以通过降低血浆粘度来降低血液流动阻力。给予己酮茶碱可降低血浆粘度。本文尝试用Bingham塑性流体模型研究非牛顿粘度在狭窄动脉中的血流行为及其意义。文中最后给出了数值算例,通过图形表示给出了流动阻力、表观粘度和壁面剪切应力的计算结果。研究表明,血流阻力、表观粘度和管壁剪切应力随狭窄的大小而增加,但由于血液的非牛顿行为,这些增加相对较小,表明其流变特性在病变动脉循环功能中的有用性。
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Achievement of Pentoxifylline for Blood Flow through Stenosed Artery
Blood-viscosity reducing drugs like “Pentoxifylline” improve blood flow by making the blood less viscous. The resistance to flow of blood in diabetic patients is higher than in non-diabetic patients. Thus diabetic patients with higher resistance to flow are more prone to high blood pressure. Therefore the resistance to blood flow in case of diabetic patients may be reduced by reducing viscosity of the plasma. Viscosity of plasma can be reducing by giving Pentoxifylline. In this paper an attempt has been made to investigate the blood flow behaviour and significance of non-Newtonian viscosity through a stenosed artery using Bingham Plastic fluid model. Numerical illustrations presented at the end of the paper provide the results for the resistance to flow, apparent viscosity and the wall shear stress through their graphical representations. It has been shown that the resistance to flow, apparent viscosity and wall shear stress increases with the size of the stenosis but these increases are comparatively small due to non-Newtonian behaviour of the blood indicating the usefulness of its rheological character in the functioning of the diseased arterial circulation.
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