血浆修饰钛表面血小板行为的体外研究

J.O. Vitoriano , C. Alves Jr. , D.C. Braz , H.A. Rocha , R.C. Lima da Silva
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引用次数: 2

摘要

引入人体的生物医学设备最初与血细胞相互作用,它们的成功取决于这种相互作用的结果。本工作旨在通过等离子体处理获得最佳的钛的生物相容性和血液相容性。为此,用不同的氮氢混合物对商业纯钛(CP)进行等离子体氮化;研究了在渗氮等离子体中加入氢气的效果。在处理前后,分别使用原子力显微镜和固滴试验对样品的形貌和润湿性进行了评估。通过将富血小板血浆(PRP)应用于修饰后的表面,并从表面张力和细胞粘附的角度分析其行为,体外评价钛的生物反应。表面性能,如粗糙度和润湿性,对氮化等离子体中的氢/氮比敏感,这表明了一种生产不同生物医学设备表面的策略。结果表明,可以获得对血小板粘附有不同反应的表面,覆盖不同的应用。
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In vitro study of platelet behaviour on titanium surface modified by plasma

Biomedical devices introduced in the human body interact initially with blood cells, their success being dependent on the result of this interaction. This work aimed to obtain optimum biocompatibility and hemocompatibility of the titanium by plasma treatment. For this, discs of commercially pure titanium (CP) were subjected to plasma nitriding using different mixture of nitrogen and hydrogen; the effect of addition of hydrogen to the nitriding plasma was investigated. Before and after treatment, samples were evaluated in terms of topography and wettability using atomic force microscopy and sessile drop tests, respectively. The titanium biological response was evaluated in vitro through the application of platelet-rich plasma (PRP) on the surfaces modified and analysis of their behaviour from the point of view of surface tension and cell adhesion. Surface properties, such as roughness and wettability, were sensitive to the hydrogen/nitrogen ratio in the nitriding plasma, suggesting a strategy for producing different surfaces of biomedical devices. Results showed to be possible to obtain surfaces with different response to the adhesion of platelets, covering different applications.

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