低强度(0.2T)静磁场对人胶质母细胞瘤细胞核固结环的分散作用

S. C. Kim, W. Im, Beom Jin Kim
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引用次数: 0

摘要

生物磁学是细胞系操纵的重要生物技术领域之一。然而,其在细胞周围水平的调控,在刺激后还不完全发达。胶质母细胞瘤U87和U251是快速生长肿瘤的恶性模型。利用静磁场的快速增长特性,研究了静磁场(0.2T=2000±600高斯)在细胞水平上的色散。结果,细胞骨架蛋白核锚蛋白G分散。透射电镜下的膜屏障显示膜器官的改变。我们的研究结果带来了一个见解,即静态磁刺激产生了一个特定的细胞质胞内模式
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Low Intensity (0.2T) Static Magnetic Field for Dispersing Nucleus AnkyrinG in Human Cultured Glioblastoma Cells
Biomagnetism is one of important biotechnology fields for manipulation of cell lines. However, its peri-cellular level regulation, upon stimulation is not fully developed. Glioblastoma U87 and U251 represent a malignant model in rapid growing cancer. We focused in cellular level dispersion of static magnetic fields (0.2T=2000 ± 600 Gauss), using its fast growing properties. As a result, cytoskeletal protein nuclear Ankyrin G was dispersed. Membrane barriers in TEM microscopy indicated the membranous apparatus change. Our findings bring an insight that static magnetic stimulation creates a specified cytoplasmic intracellular pattern
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