R. Pai, S. Pai, R. Lalitha, S. Kumaraswamy, N. Lalitha, R. Johnston, M. Bhargava
{"title":"口腔恶性黑色素瘤病例中生物标志物的鉴定及其治疗干预的潜力","authors":"R. Pai, S. Pai, R. Lalitha, S. Kumaraswamy, N. Lalitha, R. Johnston, M. Bhargava","doi":"10.5580/247f","DOIUrl":null,"url":null,"abstract":"A 32-year old female patient presented with the tumor of the oral cavity at the Kidwai Memorial Institute of Oncology, Bangalore, India. Clinical examination and histopathological analyses confirmed the neoplasm as malignant melanoma. This rare melanoma of the buccal mucosa expressed carcinoembryonic antigen (CEA) as well as contained cells that expressed elevated levels of the c-myc oncogene product as identified by immunohistochemistry of the tumor biopsy. Presence of these tumor makers in the rare case of malignant melanoma with poor prognosis should allow exploration of novel targeted therapy against CEA and c-Myc.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"31 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Identification of Biomarkers in an Oral Malignant Melanoma Case with Potential for Therapeutic Intervention\",\"authors\":\"R. Pai, S. Pai, R. Lalitha, S. Kumaraswamy, N. Lalitha, R. Johnston, M. Bhargava\",\"doi\":\"10.5580/247f\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 32-year old female patient presented with the tumor of the oral cavity at the Kidwai Memorial Institute of Oncology, Bangalore, India. Clinical examination and histopathological analyses confirmed the neoplasm as malignant melanoma. This rare melanoma of the buccal mucosa expressed carcinoembryonic antigen (CEA) as well as contained cells that expressed elevated levels of the c-myc oncogene product as identified by immunohistochemistry of the tumor biopsy. Presence of these tumor makers in the rare case of malignant melanoma with poor prognosis should allow exploration of novel targeted therapy against CEA and c-Myc.\",\"PeriodicalId\":22534,\"journal\":{\"name\":\"The Internet Journal of Oncology\",\"volume\":\"31 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/247f\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/247f","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Identification of Biomarkers in an Oral Malignant Melanoma Case with Potential for Therapeutic Intervention
A 32-year old female patient presented with the tumor of the oral cavity at the Kidwai Memorial Institute of Oncology, Bangalore, India. Clinical examination and histopathological analyses confirmed the neoplasm as malignant melanoma. This rare melanoma of the buccal mucosa expressed carcinoembryonic antigen (CEA) as well as contained cells that expressed elevated levels of the c-myc oncogene product as identified by immunohistochemistry of the tumor biopsy. Presence of these tumor makers in the rare case of malignant melanoma with poor prognosis should allow exploration of novel targeted therapy against CEA and c-Myc.