microRNA的集成跨数据库检索系统

Yijun Chen
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引用次数: 2

摘要

MicroRNAs (miRNAs)是小的非编码RNA基因产物。它在生物学和生物医学中具有重要意义。miRNA与人类疾病,特别是癌症和肿瘤密切相关。我们开发了一个miRNA信息系统,该系统集成了市场上现有的各种miRNA信息系统。该系统提供尽可能多的信息;同时,利用同步处理技术尽可能减少时间开销,利用知识发现机制减少信息冗余。使用一种特殊的机制来加快查询速度。我们通过搜索引擎从现有的关键系统中收集miRNA链接,并通过这些链接获取所有miRNA信息。然后在去除噪声和无关信息后,从中提取并分离出有用信息。然后,根据缓存数据库对综合信息进行综合合成。最后,给出了一个高效的集成跨数据库miRNA查询系统和友好的用户界面。关键词:生物信息学,microRNA, miRNA, web服务,查询系统
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An Integrated Cross-Database Search System for microRNA
MicroRNAs (miRNAs) are small noncoding RNA gene products. It is important in biology and biomedicine. The miRNA is closely related to human disease, in particular, such as cancer and tumor. We develop an information system for miRNA, which integrates a variety of existing miRNA information system on the market. The system offers as much information as possible; meanwhile it costs as less time as possible by using simultaneous processing technologies, and reduces information redundancy by knowledge discover mechanisms. A special mechanism is used to speed up the query. We collect miRNA links from existing key systems through search engine and obtain all miRNA information by these links. Then after removing noise and irrelevant ones, we extract and separate the useful information from them. After that, we synthesize and compose comprehensive information in accordance with the cache database. Finally, an effective and efficient integrated cross-database miRNA query system, as well as user friendly GUI, is provided. Key Words—bioinformatics, microRNA, miRNA, web service, query system
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