高葡萄糖增强皮肤增敏剂诱导的NRF2激活

The Open Toxicology Journal Pub Date : 2021-04-19 DOI:10.2174/1874340402107010008

Takeo Takeda, Masahiro Ogawa, J. Kitamoto, Takahiro Kyoya, M. Terada

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引用次数: 1

摘要

高血糖，即血糖水平高于2.0 g/L，是引起糖尿病晚期并发症的主要病理生理因素之一[1,2]。活性氧(Reactive Oxygen Species, ROS)因高血糖而增加[3]。单个细胞的氧化损伤可能达到足够的阈值，导致DNA链断裂并诱导细胞死亡[4]。因此，高血糖诱导的氧化应激是糖尿病并发症病理的重要因素之一。

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High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro

Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.

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The Open Toxicology Journal

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