药用植物萜类化合物的来源及其对中枢神经系统疾病的影响:综述

Luwangshangbam James Singh, Dawan Arkini Challam, Bidyarani Devi Senjam
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引用次数: 0

摘要

药用植物是次生代谢产物的丰富来源,常用于治疗和预防各种疾病。在植物次生代谢产物中,萜类化合物作为信号化合物和生长调节剂发挥着重要作用。除此之外,萜类化合物还具有药用特性,可有效用于治疗常见的中枢神经系统疾病,如抗帕金森病、抗阿尔茨海默病、抗疟疾、抗溃疡、抗肝炎等。萜类化合物还因其在提高智力、增强记忆力、发挥抗抑郁和抗焦虑作用方面的潜在作用而闻名。由于合成药物具有严重的副作用,对治疗结果产生不利影响,因此自然界中药用植物的可用性是防治各种疾病的一种指标。因此,有必要加强对药用植物中大量存在的植物化学物质储存库的研究,这对于鉴定、分离和表征针对几种疾病的特定药物生成化合物非常重要。本文综述了药用植物萜类化合物的重要潜力及其在中枢神经系统疾病中的作用。
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Medicinal plants as a sources of terpenoids and their impact on Central Nervous System disorders: A review
Medicinal plants are rich sources of secondary metabolites which are commonly used in treating and preventing various diseases. Among different secondary metabolites, terpenoids play an important role as signaling compounds and growth regulators in plants. Besides these, terpenoids also have medicinal properties which are effectively used in treating common Central Nervous System disorders such as anti-Parkinson´s disease, anti-Alzheimer’s disease, anti-malarial, anti-ulcer, hepaticidal, etc. Terpenoids were also known for their potential role in improving intelligence, memory-enhancing, and exerting antidepressant and antianxiety effects. The availability of medicinal plants in nature is an indication for combating various diseases since synthetic drugs have serious side effects that negatively affect the treatment outcome. Thus, the need to strengthen the research on reservoirs of phytochemicals that are present abundantly in medicinal plants is important for their identification, isolation, and characterization of particular drug-yielding compounds against several diseases. In this review, we have summarised the important potential of medicinal plants’ terpenoids and their effects on Central Nervous System disorders.
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