接受光动力治疗的癌症患者组织光学特性的变异性

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI:10.1109/IEMBS.2002.1053283

S. Jacques, P. Bargo, T. Goodell, R. Sleven, G. Kovall, G. Blair

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引用次数: 2

摘要

光动力疗法(PDT)利用光激活光敏药物，对肿瘤等目标组织产生氧化损伤。治疗光穿透组织并激活已积聚在目标组织中的药物的能力取决于组织的光学特性，特别是血液灌注。开发了一种内窥镜光谱探针，用于监测食管和肺组织，并在一项试点临床研究中对患者进行了测试。

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Variability of tissue optical properties in cancer patients receiving photodynamic therapy

Photodynamic Therapy (PDT) uses light to activate photosensitive drug to yield oxidative injury to targeted tissues such as cancer. The ability of treatment light to penetrate a tissue and activate the drug that has accumulated in a target tissue depends on the tissue optical properties, especially the blood perfusion. An endoscopic spectroscopic probe was developed for monitoring esophageal and lung tissues and tested in patients in a pilot clinical study.

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中国地球物理学会年刊

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368