钙生物矿物质在再生医学和组织工程中的作用

R. Upadhyay
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引用次数: 13

摘要

摘要:生物矿物质在再生医学和组织工程中的作用。在所有的生物矿物质中,钙是人体生长发育所必需的。它还在细胞代谢中发挥许多基本功能。细胞内的有机基质被磷酸钙矿物钙化。它还嵌入参与骨的维护和组织的骨细胞。本文还强调了羟基磷灰石的使用,羟基磷灰石是一种天然矿物,作为一种骨建设补充剂,与钙相比具有更好的吸收能力。它还解释了使用模拟骨组织和细胞的结构和组成的支架。这也标志着HAc微粒子或载PL微粒子、超顺磁性氧化铁纳米粒子、纳米羟基磷灰石(nHAp)和丝素蛋白(SF)复合支架在骨再生中的应用主要在成骨治疗中。为了更好和成功地进行骨再生,需要开发低成本的烧结羟基氟磷灰石椎间盘,以支持细胞增殖和定植、量身定制的矿化、细胞和药物输送。所有黏附成分应具有低免疫反应性和与天然骨组织的高生物相容性。迫切需要制造新的生物相容性材料,用于支架、生物矿物和骨再生、颅颌面外科、牙科和骨科手术的胶结制剂。
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Role of calcium bio-minerals in regenerative medicine and tissue engineering
J Stem Cell Res Ther 2017, 2(6): 00081 Abstract Present review article emphasize role of biominerals in regenerative medicine and tissue engineering. Among all biominerals calcium is essential for body growth and development. It also performs many fundamental functions in cellular metabolism. Inside cell organic matrix is calcified by calcium phosphate minerals. It also embeds bone cells which participate in the maintenance and organization of bone. This article also emphasizes use of hydroxyapatite a natural mineral used as a bone-building supplement with superior absorption in comparison to calcium. It also explains use of scaffolds that mimic the structure and composition of bone tissue and cells. It also signifies use of HAc microparticles or microparticles loaded with PL, superparamagnetic iron oxide nanoparticles, composite scaffolds of nano-hydroxyapatite (nHAp) and silk fibroin (SF) in bone regeneration mainly in osteoregenerative therapy. For better and successful bone regeneration there is a need to develop low cost sintered hydroxyfluorapatite discs to support cellular proliferation and colonization, tailored mineralization, cell and drug delivery. All adhesion components should show low immunoreactivity and high biocompatibility with natural bone tissues. There is an essential need to make new biocompatible materials for scaffolding, biomeinerals and cementing formulations for regeneration of bones, craniomaxillofacial, dental and orthopedic surgery.
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