Ameliorating Effect of Essential Phospholipids Enriched with Virgin Coconut oil (Phoscoliv®) on Alcohol Induced Liver Toxicity: Possible Role in Oxidative Stress and Cellular Leakage

Background: Researchers had shown that essential phospholipids and virgin coconut oil are the very effective agents used for the treatment of several liver disorders. Thus, the current study aimed to evaluate the ameliorating effect of Phoscoliv (PL), a novel formulation using the combination of essential phospholipids enriched with virgin coconut oil. Methods: In the study, adult wistar rats were grouped into three as Normal (N), Ethanol Treated (ET) (12.5 g/ kg body weight of 90% [v/v]) and ET+ PL (0.5 mL/100g body weight) for 30 days. Chronic administration of ethanol induced severe damage to the liver which leads to the imbalance of normal cellular and metabolic activities. It was determined by evaluating the antioxidant status, liver marker enzymes, lipid peroxidation product, pro-inflammatory cytokines and histopathological analysis. Results: Results revealed that the supplementation of PL enhance the antioxidants thereby reduced the oxidative stress associated liver damages by inhibiting lipid peroxidation product, pro-inflammatory cytokines release and leakage of liver marker enzymes. Thereby, improve the regeneration capacity of hepatic cells and maintain its normal functioning. Conclusion: Hence, PL exhibited its potent hepatoprotective activity as well as antioxidant effect against alcohol induced liver toxicity.