H. Mascaro Grosso, P. Buszniez, H. Castellini, B. Riquelme
{"title":"余甘子水提物对人红细胞粘弹性的影响:体外抗糖尿病活性","authors":"H. Mascaro Grosso, P. Buszniez, H. Castellini, B. Riquelme","doi":"10.31527/analesafa.2023.34.2.42","DOIUrl":null,"url":null,"abstract":"Phyllanthus sellowianusMüll (Klotzch) Arg. is a native plant used for diabetes treatment. It is currently of interest to evaluate its activity on the mechanical properties of human red blood cells to elucidate its mechanism of action as an antidiabetic. For this, aqueous extracts were prepared by various extractive techniques. Using the Erythrocyte Rheo-meter, the in Vitro effect on the viscoelastic parameters of glycated human red blood cells, as occurs by hyperglycemia in diabetes, was evaluated. The results obtained from the treatment with the extracts show that they affect erythrocyte viscoelasticity and can reverse the glycation effects.","PeriodicalId":41478,"journal":{"name":"Anales AFA","volume":"19 1","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EFFECT OF AQUEOUS EXTRACTS OF Phyllanthus sellowianusON THE VISCOELASTICPROPERTIES OF HUMAN RED BLOOD CELLS:IN VITRO ANTIDIABETIC ACTIVITY\",\"authors\":\"H. Mascaro Grosso, P. Buszniez, H. Castellini, B. Riquelme\",\"doi\":\"10.31527/analesafa.2023.34.2.42\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Phyllanthus sellowianusMüll (Klotzch) Arg. is a native plant used for diabetes treatment. It is currently of interest to evaluate its activity on the mechanical properties of human red blood cells to elucidate its mechanism of action as an antidiabetic. For this, aqueous extracts were prepared by various extractive techniques. Using the Erythrocyte Rheo-meter, the in Vitro effect on the viscoelastic parameters of glycated human red blood cells, as occurs by hyperglycemia in diabetes, was evaluated. The results obtained from the treatment with the extracts show that they affect erythrocyte viscoelasticity and can reverse the glycation effects.\",\"PeriodicalId\":41478,\"journal\":{\"name\":\"Anales AFA\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2023-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anales AFA\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31527/analesafa.2023.34.2.42\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anales AFA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31527/analesafa.2023.34.2.42","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
EFFECT OF AQUEOUS EXTRACTS OF Phyllanthus sellowianusON THE VISCOELASTICPROPERTIES OF HUMAN RED BLOOD CELLS:IN VITRO ANTIDIABETIC ACTIVITY
Phyllanthus sellowianusMüll (Klotzch) Arg. is a native plant used for diabetes treatment. It is currently of interest to evaluate its activity on the mechanical properties of human red blood cells to elucidate its mechanism of action as an antidiabetic. For this, aqueous extracts were prepared by various extractive techniques. Using the Erythrocyte Rheo-meter, the in Vitro effect on the viscoelastic parameters of glycated human red blood cells, as occurs by hyperglycemia in diabetes, was evaluated. The results obtained from the treatment with the extracts show that they affect erythrocyte viscoelasticity and can reverse the glycation effects.
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