中性粒细胞与淋巴细胞比值在评估哮喘及其严重程度中的临床应用

R. Tahseen, M. Parvez, P. Jahan
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引用次数: 0

摘要

免疫系统的稳态是由细胞介导的免疫炎症反应调节的。免疫反应的变化明显地反映在细胞比率而不是单个细胞计数上。中性粒细胞与淋巴细胞比率(NLR)是一种良好的炎症标志物,在各种炎症相关疾病中得到了研究。哮喘是一种慢性炎症性气道疾病,伴有高反应性、反复发作、喘息、咳嗽和胸闷,并伴有粒细胞多细胞涌入,伴有轻度至重度NLR症状和改变。本研究的目的是探讨哮喘NLR的现有文献,以了解其在哮喘及其严重程度中的临床应用。截至目前(2022年5月20日),我们检索了在线数据库资源“PubMed”和“Google Scholar”,并根据入选标准纳入了研究。对收集到的数据进行了审查和分析。该研究包括八篇关于NLR和哮喘的已发表文章。分析显示,健康对照组与哮喘患者的平均NLR差异有统计学意义(1.57±0.35∶2.36±0.30;P < 0.0001);此外,与非严重哮喘患者相比,严重哮喘患者和非严重哮喘患者的平均NLR最高(4.82±2.85∶2.13±0.17;P < 0.0001)。NLR的受试者工作曲线分析显示,NLR对健康与疾病、控制与非控制具有良好的区分能力。这一小型综述表明,NLR可以作为一种非昂贵、非侵入性的监测工具,以降低病情恶化和住院的风险。然而,大规模的研究是有必要的。
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Clinical utility of neutrophil-to-lymphocyte ratio in the assessment of asthma and its severity
Homoeostasis of the immune system is regulated by cell-mediated immune-inflammatory responses. The shift of the immune response is clearly reflected by the cellular ratios than individual cell count. Neutrophil-to-lymphocyte ratio (NLR) serves as a good cell-based marker of inflammation, which is being investigated in various inflammation-related diseases. Asthma which is a chronic inflammatory airway disease associated with hyperresponsiveness, recurrent attacks, wheezing, coughing and chest tightness coupled with multicellular influx of granulocytes with mild-to-severe symptoms of and altered NLR. The aim of the present study was to explore the existing literature on NLR in asthma to realise its clinical utility in asthma and its severity. We searched online database resources 'PubMed' and 'Google Scholar' up till now (20th May, 2022), and studies were included as per eligibility criteria. The data collected were reviewed and analysed. The study included eight published articles on NLR and asthma. The analysis revealed that there is a significant difference in mean NLR between healthy controls and asthma patients (1.57 ± 0.35 vs. 2.36 ± 0.30; P < 0.0001); further, severe versus non-severe asthma cases showed the highest mean NLR as compared to non-severe cases (4.82 ± 2.85 vs. 2.13 ± 0.17; P < 0.0001). Receiver operating curve analysis of NLR showed excellent discriminating capacity, for health versus disease and controlled versus uncontrolled. This mini review suggests NLR can serve as a non-expensive, non-invasive monitoring tool to reduce the risk of exacerbation and hospitalisation. However, large studies are warranted.
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