半胱氨酸对胸苷基-(5 ' -3 ')-溴脱氧尿苷光化学分解的影响

A. Haug
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引用次数: 7

摘要

用单色紫外光照射胸苷基-(5 ' -3 ')-溴脱氧尿嘧啶溶液,产生一个主要的光产物,即不含溴和环丁烯环结构的分子内二聚体。在半胱氨酸存在和紫外线辐射下,二聚体进一步分解为具有末端吸收光谱特征的光产物。该化合物每个二核苷酸含有一个S原子,不能通过2400 Å照射还原。巯基加成的量子产率是作为波长的函数来测量的。讨论了反应动力学及其可能具有辐射防护作用的生物学意义。
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Influence of cysteine on the photochemical decomposition of thymidyl-(5′-3′)-bromodeoxyuridine

Irradiating a solution of thymidyl-(5′-3′)-bromodeoxyuridine with monochromatic, ultraviolet light yields one main photo-product, an intramolecular dimer, containing no Br and a cyclobutene ring structure. In the presence of cysteine and ultraviolet radiation the dimer is further decomposed to a photo-product characterized by an end-absorption spectrum. This compound contains one S atom per dinucleotide and cannot be reverted by irradiation at 2400 Å. The quantum yields of this sulfhydryl addition are measured as a function of wavelength. The reaction kinetics and the biological implication of this process, which is possibly radio-protective, are discussed.

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Subject index Author index Photoreduction of nicotinamide-adenine dinucleotide by a cell-free system from Chromatium Chlorophylls of photosynthetic bacteria Photodimerization of urocanic acid in vitro and in vivo
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