通过“点击化学”获取八糖基化卟啉的便捷方法

Misako Okada, Yuko Kishibe, Kanako Ide, Toshiyuki Takahashi, Teruaki Hasegawa
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引用次数: 14

摘要

通过携带8个炔端卟啉和-乳糖基叠氮化物的卟啉之间的催化化学选择性偶联(点击化学),实现了8个-乳苷模块在卟啉核心上的简单、定量和一锅式引入。所制得的卟啉基糖簇不仅具有良好的水溶性,而且具有很强的/特异性凝集素亲和力。
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Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”
Easy, quantitative, and one-pot introduction of eight -lactoside-modules onto a porphyrin-core was achieved through -catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals and -lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.
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