{"title":"人类乙酰胆碱酯酶(AChE)与抑制剂小分子的对接研究","authors":"郑清川, 楚慧郢, 牛瑞娟, 孙家锺","doi":"10.1360/ZB2009-39-11-1454","DOIUrl":null,"url":null,"abstract":"阿尔茨海默病(Alzheimer’s disease, AD)是一种中枢神经系统致死性神经原发性退行病变, 是老年痴呆症中最常见的一种类型. 乙酰胆碱酯酶抑制剂(AChEI)是目前治疗AD的主要药物. 我们选择他克林、利伐斯的明、石杉碱甲、在研药物TV-3326、多奈哌齐和Anseculin, 分别与AChE进行分子对接研究. 结果表明: 抑制剂与AChE结合能力的大小顺序为: 他克林＜利伐斯的明＜石杉碱甲＜TV-3326＜多奈哌齐＜Anseculin, 这与实验中测得AChEI的IC 50 值反应活性大小一致. 上述6类药物分子, Anseculin与AChE的相互作用能力最强.","PeriodicalId":49128,"journal":{"name":"Science in China. Series B, Chemistry","volume":"43 1","pages":"1454-1460"},"PeriodicalIF":0.0000,"publicationDate":"2009-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"人类乙酰胆碱酯酶(AChE)与抑制剂小分子的对接研究\",\"authors\":\"郑清川, 楚慧郢, 牛瑞娟, 孙家锺\",\"doi\":\"10.1360/ZB2009-39-11-1454\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"阿尔茨海默病(Alzheimer’s disease, AD)是一种中枢神经系统致死性神经原发性退行病变, 是老年痴呆症中最常见的一种类型. 乙酰胆碱酯酶抑制剂(AChEI)是目前治疗AD的主要药物. 我们选择他克林、利伐斯的明、石杉碱甲、在研药物TV-3326、多奈哌齐和Anseculin, 分别与AChE进行分子对接研究. 结果表明: 抑制剂与AChE结合能力的大小顺序为: 他克林＜利伐斯的明＜石杉碱甲＜TV-3326＜多奈哌齐＜Anseculin, 这与实验中测得AChEI的IC 50 值反应活性大小一致. 上述6类药物分子, Anseculin与AChE的相互作用能力最强.\",\"PeriodicalId\":49128,\"journal\":{\"name\":\"Science in China. Series B, Chemistry\",\"volume\":\"43 1\",\"pages\":\"1454-1460\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science in China. Series B, Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1360/ZB2009-39-11-1454\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science in China. Series B, Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1360/ZB2009-39-11-1454","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
