肠病性肢端皮炎误诊为葡萄球菌性烫伤皮肤综合征1例

P. Bisht, A. Sood
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引用次数: 0

摘要

肠病性肢端皮炎(AE)是一种罕见的遗传常染色体隐性遗传病,其特征是由于缺锌引起的周周皮炎,脱发和腹泻。我们报告一例9个月大的男婴,脱发2个月,腹泻1.5个月,口、鼻、肛门周围皮肤开始脱皮,1个月以上逐渐扩散全身,发热10天。由于过量的细菌感染和临床表现的改变,他被诊断为葡萄球菌烫伤皮肤综合征。血清锌水平低,口服锌治疗8天内皮肤病变和腹泻改善,确认为肠病性肌端皮炎。对于伴有肢端和/或围周皮肤病变的儿童慢性腹泻病例,应将AE作为鉴别诊断之一,以防止补锌治疗的延误和死亡率。
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A case of acrodermatitis enteropathica misdiagnosed as staphylococcal scalded skin syndrome
Acrodermatitis enteropathica (AE) is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea due to zinc deficiency. We report a case of a 9-month-old baby boy with hair loss for 2 months, diarrhea for 1.5 months, skin peeling starting around mouth, nose, anus, gradually spreading all over body over 1 month, and fever for 10 days. Due to superadded bacterial infections and altered clinical picture, he was diagnosed as a case of staphylococcal scalded skin syndrome. With low serum zinc levels and improvement of skin lesions and diarrhea within 8 days of starting oral zinc therapy, it was confirmed to be a case of acrodermatitis enteropathica. It is important to consider AE as one of the differential diagnoses in pediatric chronic diarrhea cases with acral and/or periorificial skin lesions to prevent delay in the zinc supplementation treatment and mortality.
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