海参中阿魏酰酯等三萜的分离及毒性评价

F. Rwegoshora, F. Mabiki, F. Machumi, M. Chacha, B. Styrishave, C. Cornett
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引用次数: 1

摘要

利用植物作为药物的来源主要是由于植物易于获取、毒性小、很少或没有耐药性等因素。传统医学和药物发现领域的进步都需要对任何具有药用价值的植物中的纯化合物进行研究。大戟科的银盆草(Synadenium glaucescens Pax)是坦桑尼亚被证明含有抗微生物感染的生物活性化合物的药用植物之一。对根皮和茎皮的乙醇和甲醇提取物分别进行分析,分离得到6个纯化合物(SG1- 6)。通过1D、2D NMR和GC-MS对这些化合物进行了分析,并在Bruker TopSpin 3.6.2中对其进行了光谱处理。其中,1个是酚类化合物(半甘油酯阿魏酸- sg1)、3个三萜化合物(鹿皮醇- SG2、表戊香醇- SG4和大戟醇- sg5)、1个类固醇化合物(β-谷甾醇- SG6)和一个长链烯烃(1-壬烯- SG2)。盐水对虾致死试验(BLST)的细胞毒性评价表明,所报道的化合物实际上是无毒的。
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Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax
The use of plants as sources of drug agents is attributed by factors among which are the easy accessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditional medicine and drug discovery field necessitates investigation of pure compounds in any plant with medicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plant in Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis of ethanolic and methanolic extracts of root and stem barks respectively aided to isolated six pure compounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while their spectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was a phenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and eupholSG5), one steroid (β-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicity evaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practically non-toxic.
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