Analysis of clinical features and related risks of prognosis in 68 non-human immunodeficiency virus immunosuppressed patients with cytomegalovirus pneumonia

Objective To analyze the clinical characteristics of 68 non-human immunodeficiency virus immunosuppressed patients with cytomegalovirus pneumonia, and the risk factors related to death, so as to provide reference for clinical diagnosis and treatment. Methods A retrospective case analysis study was used.The clinical data of 68 patients with cytomegalovirus pneumonia admitted to the Second Department of Respiratory Medicine of the Second Hospital of Hebei Medical University were collected.According to the patient′s 28d outcome, the patients were divided into the survival group and the death group.The general conditions and clinical data of the two groups were compared, and risk factors were analyzed. Results The top three underlying diseases were kidney disease, rheumatic disease, and blood system disease.In the death group, the acute physiology and chronic health evaluation Ⅱ scores, hypersensitive C-reactive protein, the smallest absolute counts of white blood cells, neutrophil percentage were higher than those in the survival group (all P<0.05), and the absolute counts of lymphocyte, CD3+ lymphocyte, CD4+ lymphocyte were lower (all P<0.05). Long-term (more than three months) application of glucocorticoids or combination with immunosuppressive agents were significantly more in the death group (all P<0.05). The immunosuppressed patients who suffered from dermatological disease, had gram-positive coccal pneumonia or bloodstream infections, needed mechanical ventilation had a poor prognosis (all P<0.05). Conclusions Cytomegalovirus pneumonia patients who received long-term (more than three months) application of glucocorticoids or combination with immunosuppressive agents, had gram-positive coccal pneumonia or bloodstream infections, and needed mechanical ventilation have a poor prognosis. Key words: Cytomegalovirus pneumonia; Respiratory insufficiency; T lymphocyte subsets; Prognosis