使用回放转换的核苷酸变形

B. Kathiresan, G. Karthik
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引用次数: 0

摘要

生物信息学是应用计算机技术对生物数据进行管理和分析的学科。DNA序列的模式匹配或从大型数据库中搜索模式是计算生物学的一个主要研究领域。基因组学领域的主要问题之一是如何对DNA和蛋白质序列进行模式比较。一条完整的DNA链包含30亿个核苷酸碱基。为了解析和转换大量的氨基酸,现有的方法需要几分钟。如果转换过程中途中止,它将重新开始。为了克服这个缺点,建议使用重放转换方法从中断的地方继续进程。并且该方法在并行模式下的后续实现将减少现有方法所花费的时间的40%。这篇论文完全集中在一种方法,以减少所需的时间为核苷酸转化为氨基酸。该技术在DNA序列分析方面具有很好的性能,可用于查询公开可用的基因组序列数据。这些实验结果表明,在整体性能的提高上有相当大的提高。
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Nucleotide transfigurations using playback conversion
Bioinformatics is the application of computer technology for the management and analysis of biological data. Pattern matching in a DNA sequence or searching a pattern from a large data base is a major research area in computational biology. One of the major problems in genomic field is to perform pattern comparison on DNA and protein sequences. A full DNA strand contains three billion of nucleotide bases. To parse and to convert amino acids of high volume, the existing approach takes some minutes. If the conversion process is aborted in middle, it will restart from the beginning again. In order to overcome this drawback, the playback conversion approach is proposed to continue the process from where it aborted. And the subsequent implementation of this approach in parallel mode will reduce forty percent of time taken by the existing approach. This paper entirely focuses on an approach to reduce the time taken for the conversion of nucleotide to amino acids. The proposed technique gives very good performance related to DNA sequence analysis for querying of publicly available genome sequence data. These experimental results show that there is considerable increase in the improvement of overall performance.
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