Hand- Foot Syndrome And Cutaneous Reactıons Followıng Fırst Dose Of Chemotherapy

A 63-year-old female with stage IIIA breast cancer was treated in our department with adjuan chemotherapy containing 5fluoruracil,epirubicine and cyclophosphamide. Clinical and anamnetic findings revealed no signs of any disorder and physical examination was unremarkable. The patient received, 5fluoruracil 720 mg/m 2 , epirubicine 145mg/m and cyclophosphamide 720 mg/m administered as a infusion on day one, repeated every three weeks. Treatment given on day 1 was preceded by dexametasone 4 mg i.v. and granisetron 3 mg i.v. for the prophylaxis of nausea and vomiting. The same anti-emetic treatment was repeated i.v.on day 2 and orally on days 3 and 4. The first treatment cycle was uneventful. Four days after administration of the second cycle the patient was admitted to our clinic with hand-foot syndrome(HFS), associated with nail changes on hand (hyperpigmentation) and maculopapuler eruptions on the trunk(Figure 1,2,3,4 and 5).