利用直接力测量确定神经细胞粘附分子(NCAM)功能的机制

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI:10.1109/IEMBS.2002.1134524

D. Leckband, C. Johnson, R. A. Roberts, I. Fujimoto, B. Anderson, U. Rutishauser

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引用次数: 0

摘要

采用直接力测量的方法研究了神经细胞粘附分子(NCAM)间亲同性粘附的分子机制。力-距离分布表明，粘附过程涉及多个区域。此外，多唾液化对蛋白间力的影响为翻译后修饰调节NCAM功能的分子机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Using direct force measurements to determine the mechanism of neural cell adhesion molecule (NCAM) function

The molecular mechanism of homophilic adhesion between neural cell adhesion molecules (NCAM) was investigated by direct force measurements. The force-distance profiles demonstrated that multiple domains are involved in adhesion. In addition, the effect of polysialylation on the interprotein forces provided insights into the molecular mechanism by which posttranslational modification regulates NCAM function.

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来源期刊

中国地球物理学会年刊

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