Efficacy and adverse reactions of three-dimensional conformal low fractionated radiotherapy combined with gefitinib in the treatment of elderly non-small cell lung cancer

Objective To evaluate the efficacy and side effects of three-dimensional conformal low-segment radiotherapy (3D-CRT) combined with gefitinib in the treatment of elderly non-small cell lung cancer (NSCLC). Methods Ninety elderly patients with NSCLC treated in Shanxi Provincial Cancer Hospital from March 2017 to January 2019 were selected as the object of this study. The 90 elderly NSCLC patients were randomly divided into control group (45 cases) and observation group(45 cases) according to envelope randomized grouping scheme. The control group was treated with gefitinib, and the observation group was treated with 3D-CRT on the basis of the control group. The short-term efficacy, quality of life and adverse reactions between the two groups were compared. Results After the corresponding treatment, the KPS score of observation group of was higher than that of control group (P 0.05). Conclusions 3D-CRT combined with gefitinib can improve the quality of life of elderly NSCLC patients, and the safety is good. Key words: Non-small cell lung cancer; Elderly patients; Three-dimensional conformal low-level radiotherapy; Gefitinib