尼日利亚肝细胞癌患者的丙型肝炎病毒抗体

S. Mustapha, M. T. Bolori, N. Ajayi, H. Nggada, U. Pindiga, W. Gashau, M. Khalil
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引用次数: 8

摘要

目的:本研究的目的是确定尼日利亚肝细胞癌患者中丙型肝炎病毒抗体的频率。方法:前瞻性研究。对组织学证实的肝细胞癌患者进行研究。使用第三代ELISA检测患者血清中的丙型肝炎病毒抗体。结果:共纳入108例患者,其中男性81例,女性27例,男女比例为4:1。年龄22 ~ 75岁,平均48岁(SD±13.0)。肝细胞癌发病率最高的年龄段为4049岁。HCV抗体阳性19例(17.6%)。在男性和女性患者中,这些抗体的频率没有显著差异。结论:HCV在尼日利亚肝细胞癌的病因学中起重要作用。因此,慢性丙型肝炎患者应定期进行HCC筛查。
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Hepatitis C Virus Antibodies In Nigerians With Hepatocellular Carcinoma
Objective: The aim of the study is to determine the frequency of antibodies to hepatitis C virus among Nigerian patients with hepatocellular carcinoma. Method: The study was prospective. Patients with histologically confirmed hepatocellular carcinoma were studied. Sera of the patients were tested for hepatitis C virus antibodies using a third generation ELISA. Results: A total of 108 patients consisting of 81 males and 27 females were studied, giving a male to female ratio of 4:1. Their ages ranged from 22 to 75 years with a mean of 48 years (SD±13.0). The highest incidence of hepatocellular carcinoma was found among those aged 4049 years. A total of 19 patients (17.6%) were positive for HCV antibodies. There was no significant difference in the frequencies of these antibodies between the male and female patients. Conclusion: HCV plays a significant role in the etiology of hepatocellular carcinoma in Nigeria. Therefore, patients with chronic hepatitis C should be screened for HCC on regular basis.
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