Yimiao He , Jingwen Yuan , Wen-Xin Lv , Peng Liu , Fan Teng , Qijin Mo , Zihua Wu , Chusheng Huang , Qianwen Liu , Honggen Wang
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Simple nucleophile/H2O promoted defluorinative ring-opening of gem-difluorocyclopropenes
A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents. Water plays a crucial role in this transformation.
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