纳米材料作为检测和对抗病毒的诊断工具

Rama Sharma
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引用次数: 0

摘要

全世界死亡的主要原因是传染病,特别是病毒,对全世界的健康和经济增长产生重大影响。一个关键的公共卫生问题是对目前可获得的治疗方法的耐药性迅速出现,以及反复使用产生的负面副作用。因此,制定新的治疗方案是必要的。与传统的基于化学的抗病毒药物相比,纳米颗粒的使用为开发具有最小耐药性风险的创新抗病毒疗法提供了诱人的潜力。纳米材料使得改变可获得资源的性质变得简单。纳米材料可以很容易地用于修改现有的检测平台,以提高其灵敏度。由于它们的高表面体积比,NPs很容易与病毒膜蛋白或病毒繁殖系统(DNA/RNA)结合,从而阻碍病毒感染细胞的能力。金属纳米颗粒(NPs)如金、银和铜的使用抑制了病毒的增殖。由于铜比银和金的成本更低,它的抗菌性能已经被反复研究过。病毒在铜表面4小时后失活,这增加了铜可以用来破坏感染的可能性。此外,研究人员还发现,50%的病毒样颗粒(VLPs)可以在10分钟内被铜复合纳米颗粒使其失去活性。医学界可以从复杂的智能手机和/或基于lfa的检测技术中受益匪浅,这些技术可以在病人的床边使用。本文综述了基于纳米技术的诊断和治疗病毒性疾病的方法,特别是艾滋病毒和流感。
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Nanomaterials As Theragnostic Tools of Detection and Fighting off the Virus
The primary cause of death worldwide is an infectious disease, and viruses in particular, have a major worldwide impact on health and economic growth. A critical public health problem is the quick emergence of medication resistance to currently accessible treatments as well as negative side effects from repeated use. Therefore, the creation of novel treatment plans is necessary. In contrast to conventional chemical-based antiviral drugs, the use of nanoparticles offers an alluring potential for the development of innovative antiviral therapies with minimal risk of acquiring drug resistance. Nanomaterials make it simple to change the properties of accessible resources. Nanomaterials can be readily applied to modify the available detection platforms to improve their sensitivity. Due to their high surface-to-volume ratio, NPs readily bind to either the viral membrane proteins or the viral reproduction system (DNA/RNA), thus hindering the virus' ability to infect cells. Viral proliferation has been inhibited by the use of metal nanoparticles (NPs) such as gold, silver, and copper. Copper has repeatedly been examined for its strong anti-microbial qualities due to its lower cost than silver and gold. The virus's inactivation on copper surfaces after 4 hours raises the possibility that copper could be used to destroy the infection. Also, it was discovered that 50% of virus-like particles (VLPs) could be rendered inactive by copper composite nanoparticles in just 10 minutes. The medical community could benefit greatly from sophisticated smartphone and/or LFA-based detection techniques that can be used right at the patient's bedside. This review discusses methods based on nanotechnology for diagnosing and treating viral diseases, especially HIV and influenza.
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来源期刊
Nanoscience and Nanotechnology - Asia
Nanoscience and Nanotechnology - Asia Engineering-Engineering (all)
CiteScore
1.90
自引率
0.00%
发文量
35
期刊介绍: Nanoscience & Nanotechnology-Asia publishes expert reviews, original research articles, letters and guest edited issues on all the most recent advances in nanoscience and nanotechnology with an emphasis on research in Asia and Japan. All aspects of the field are represented including chemistry, physics, materials science, biology and engineering mainly covering the following; synthesis, characterization, assembly, theory, and simulation of nanostructures (nanomaterials and assemblies, nanodevices, nano-bubbles, nano-droplets, nanofluidics, and self-assembled structures), nanofabrication, nanobiotechnology, nanomedicine and methods and tools for nanoscience and nanotechnology.
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