磷酸三钙在酸化溶液中的表征及溶解动力学

M. Sader, Denisar Ismério, M. C. Andrade, G. D. Soares, I. Bastos, G. Platt
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摘要

用于生物医学应用的生物陶瓷必须具有特定的性能。例如,在支架中,生物陶瓷的可降解性对于细胞的生长至关重要。因此,磷酸钙的溶解增加了种植体-骨界面周围的离子浓度,有利于骨更快地附着到移植体表面。溶解发生在静态或动态条件下,但后者通常不是在严格的水动力控制下进行的。本文采用压制和烧结的方法制备了β-磷酸三钙和镁代磷酸三钙两种生物陶瓷。采用XRD、Raman、ICP、SEM、AFM和光度测试对其进行了表征。通过严格控制水动力条件,进行了化学成分对溶解试验的影响。圆盘以精确的速度旋转,以便在良好控制的传质下产生溶解。随后,在pH =约4的模拟感染环境中评估钙释放。因此,有可能在较大转速范围内评估与传质或表面反应有关的溶解分数。与纯磷酸三钙相比,添加到生物陶瓷中的镁抑制了总溶解,这可能与陶瓷密度更大,可溶性更低有关。此外,传质对磷酸三钙镁的影响相对小于纯磷酸三钙。
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Characterization and Dissolution Dynamics of Tricalcium Phosphates in Acidified Solution
Bioceramics used in biomedical applications must exhibit specific behaviors. In scaffolds, for instance, the degradability of bioceramics is important to allow the cell ingrowth. Therefore, the dissolution of calcium phosphates increases the ionic concentrations around the interface implant–bone, favoring a more rapid bone apposition to the graft surface. The dissolution takes place under static or dynamic conditions, but the latter is usually not performed under rigorous hydrodynamic control. In the present work, two bioceramics, β-tricalcium phosphate and β-tricalcium phosphate substituted by magnesium, were produced by pressing and sintering to form disks. They were characterized by XRD, Raman, ICP, SEM, AFM and photometric test. The influence of chemical composition in the dissolution test was conducted through strict control of the hydrodynamic conditions. The disks were rotating in a precise speed, in order to produce a dissolution under the well-controlled mass transfer. Subsequently, the calcium release was evaluated in a simulated infectious environment using pH equals to circa 4. Thus, it was possible to evaluate the fraction of dissolution related to mass transfer or surface reactions for a large rotation speed range. The magnesium added to the bioceramic inhibits the total dissolution when compared to pure tricalcium phosphate, probably related to more dense and less soluble ceramic. Moreover, the mass transfer affects relatively less the magnesium tricalcium phosphate than pure tricalcium phosphate.
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