区域谱比作为识别阿尔茨海默病相关轻度认知障碍的潜在神经标志物。

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2023-04-01 DOI:10.1017/neu.2022.18
Tien-Wen Lee, Gerald Tramontano
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引用次数: 2

摘要

目的:阿尔茨海默病(AD)具有较长的无症状期或轻度症状期。考虑到治疗选择的增加和早期干预可以改变疾病进程,设计可以区分轻度认知障碍(MCI)阶段AD和非AD的生物学指标是必要的。方法:基于两个公认的背景变慢(α功率衰减,θ和δ功率增强)和早期累及后扣带皮层(PCC,默认模式网络的神经中枢)的观察结果,本研究设计了新的神经标记,即在PCC中α 1与δ和α 1与θ的频谱比。结果:我们分析了46例MCI患者,其中22例ADMCI患者和24例非ADMCI患者,他们在年龄、教育程度和全球认知能力方面相匹配。与预测一致,ADMCI组的区域谱比较低,提示其临床应用潜力。结论:已有研究证实,临床脑电图神经标记物可用于区分AD与其他神经系统疾病。我们认为,显示早期病理变化的神经中枢的频谱比可以丰富MCI(或临床前)阶段脑功能障碍的工具评估。
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Regional spectral ratios as potential neural markers to identify mild cognitive impairment related to Alzheimer's disease.

Objective: Alzheimer's disease (AD) has prolonged asymptomatic or mild symptomatic periods. Given that there is an increase in treatment options and that early intervention could modify the disease course, it is desirable to devise biological indices that may differentiate AD and nonAD at mild cognitive impairment (MCI) stage.

Methods: Based on two well-acknowledged observations of background slowing (attenuation in alpha power and enhancement in theta and delta powers) and early involvement of posterior cingulate cortex (PCC, a neural hub of default-mode network), this study devised novel neural markers, namely, spectral ratios of alpha1 to delta and alpha1 to theta in the PCC.

Results: We analysed 46 MCI patients, with 22 ADMCI and 24 nonADMCI who were matched in age, education, and global cognitive capability. Concordant with the prediction, the regional spectral ratios were lower in the ADMCI group, suggesting its clinical application potential.

Conclusion: Previous research has verified that neural markers derived from clinical electroencephalography may be informative in differentiating AD from other neurological conditions. We believe that the spectral ratios in the neural hubs that show early pathological changes can enrich the instrumental assessment of brain dysfunctions at the MCI (or pre-clinical) stage.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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