壳聚糖水凝胶及其戊二醛交联对应物作为潜在药物释放和组织工程系统的合成、表征、溶胀动力学和机理

O. Akakuru, B. Isiuku
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引用次数: 63

摘要

以蜗牛壳为原料制备壳聚糖,制备壳聚糖水凝胶,并与不同量的戊二醛交联,交联密度在0.75 ~ 1.50之间。材料的溶胀性随时间和ph值的变化而变化。FTIR分析结果显示,在3451 cm-1处有一个条带,这是壳聚糖的O-H拉伸引起的。与未交联壳聚糖水凝胶在1652 cm-1处的N-H弯曲振动相比,交联壳聚糖水凝胶在1635 cm-1处的N-H弯曲振动强度降低,且波数更低。溶胀研究表明,水凝胶的溶胀程度与交联密度(CD)有关,随交联密度的增大而增大。未交联壳聚糖水凝胶最大溶胀率为162.71%,而CD为0.75、1.00和1.50的交联壳聚糖水凝胶最大溶胀率分别为119.87%、93.21%和87.65%。在所有情况下,它们的交联对应物的溶胀性都降低了,这表明,交联壳聚糖水凝胶可以用于更可控的药物输送,并作为组织工程的有效材料。壳聚糖水凝胶在高酸性介质(pH2)中具有最大的溶胀性,这表明壳聚糖水凝胶在高酸性介质中具有作为药物释放系统的潜力。壳聚糖水凝胶的溶胀服从二级动力学,溶胀扩散指数在0.142 ~ 0.155之间,属于Less Fickian扩散或输运模式。
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Chitosan Hydrogels and their Glutaraldehyde-Crosslinked Counterparts as Potential Drug Release and Tissue Engineering Systems - Synthesis, Characterization, Swelling Kinetics and Mechanism
Snail shells had been utilized to prepare chitosan and hydrogels of the chitosan were also prepared and crosslinked with varying amounts of glutaraldehyde to achieve different crosslink densities between 0.75 and 1.50. The materials were characterized in terms of the dependence of their swellabilities on time and pH. FTIR analysis was also carried out on the hydrogels and the results obtained show a band at 3451 cm-1, attributed to O-H stretching of the chitosan. The crosslinked hydrogels also showed an N-H bending vibration at 1635 cm-1 which has a reduced intensity and has moved to a lower wavenumber when compared to the N-H bending vibration of the uncrosslinked chitosan hydrogels at 1652 cm-1. The swelling studies showed that the extent of swelling of the hydrogels was dependent on the crosslink density (CD), increasing as CD increased. Uncrosslinked chitosan hydrogel had maximum swelling of 162.71% while that for the crosslinked chitosan hydrogels with CD of 0.75, 1.00 and 1.50 were 119.87%, 93.21% and 87.65% respectively. In all cases, their crosslinked counterparts had decreased swellabilities suggesting that, the crosslinked chitosan hydrogels can be used for a more controlled delivery of drugs and as efficient materials for tissue engineering. The chitosan hydrogels showed maximum percent swellability in highly acidic medium (pH2) equally suggesting the potential of these hydrogels as drug release systems in this medium. The swelling of the chitosan hydrogels followed second-order kinetics and their swelling diffusion exponents ranged from 0.142 to 0.155, indicative of a Less Fickian diffusion or transport mode.
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