心室辅助装置中剪切应力相关溶血的分析。

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2023-01-01 DOI:10.3233/BME-221401
Mohamed Bounouib, Hind Benakrach, Mourad Taha-Janan, Wajih Maazouzi
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引用次数: 0

摘要

背景:植入式装置如心室辅助装置为晚期心力衰竭患者提供了适当的治疗。不幸的是,这些设备仍然存在许多问题,特别是与血液损伤有关的问题。目的:本研究的目的是研究两种新的心室辅助装置在诱导剪切应力、暴露时间和诱导溶血方面的作用。方法:对多个轴流式心室辅助装置进行逆向工程,收集与设计相关的所有细节(直径、长度、叶片角度等),并建立A型和b型两种样机。结果:所得结果在很大程度上接近,除了静压上升差异明显。结论:与已发表的研究结果相比,两种模型的综合性能均较好。
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Analysis of shear stress related hemolysis in a ventricular assist device.

Background: Implantable devices such as ventricular assist devices provide appropriate treatment for patients with advanced heart failure. Unfortunately, these devices still have many problems, particularly related to blood damage.

Objective: The aim of this research is to examine two new ventricular assist devices in terms of induced shear stress, exposure time, and induced hemolysis.

Method: Reverse engineering was used on multiple axial flow ventricular assist devices to collect all the details related to the designs (diameters, lengths, blade angles…), which were used to build two prototypes: Model A and Model B.

Results: The obtained results were close to a large extent, except for static pressure rise, where the difference was clear.

Conclusion: Compared with what has been published in other studies, the overall performance of both models was excellent.

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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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