{"title":"加替沙星金属配合物的合成、表征及生物活性评价","authors":"N. Dave, H. Bhatt","doi":"10.9734/ajocs/2021/v10i419109","DOIUrl":null,"url":null,"abstract":"The antibiotic agent Gatifloxacin is well known for its drug design and coordinating ability towards metal ions. In this paper, synthesis and biological activity of Mn(II), Co(II), Ni(II), Cu(II) and Mg(II) complexes of gatifloxacin is reported. Ligand is itself prepared using o-phenylenediamine (OPD) and 3-acetyl coumarin. The structure of complexes has been investigated using some physiochemical and spectroscopic techniques. In vitro evaluation of these complexes was also carried out for antibacterial and antimicrobial activity. Some complexes exhibited promising anti-bacterial and antimicrobial activity compared to gatifloxacin drug.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":"68 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Metal Complexes of Gatifloxacin: Synthesis, Characterization and Evaluation of Biological Activity\",\"authors\":\"N. Dave, H. Bhatt\",\"doi\":\"10.9734/ajocs/2021/v10i419109\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antibiotic agent Gatifloxacin is well known for its drug design and coordinating ability towards metal ions. In this paper, synthesis and biological activity of Mn(II), Co(II), Ni(II), Cu(II) and Mg(II) complexes of gatifloxacin is reported. Ligand is itself prepared using o-phenylenediamine (OPD) and 3-acetyl coumarin. The structure of complexes has been investigated using some physiochemical and spectroscopic techniques. In vitro evaluation of these complexes was also carried out for antibacterial and antimicrobial activity. Some complexes exhibited promising anti-bacterial and antimicrobial activity compared to gatifloxacin drug.\",\"PeriodicalId\":8505,\"journal\":{\"name\":\"Asian Journal of Chemical Sciences\",\"volume\":\"68 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Chemical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.9734/ajocs/2021/v10i419109\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Chemical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/ajocs/2021/v10i419109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metal Complexes of Gatifloxacin: Synthesis, Characterization and Evaluation of Biological Activity
The antibiotic agent Gatifloxacin is well known for its drug design and coordinating ability towards metal ions. In this paper, synthesis and biological activity of Mn(II), Co(II), Ni(II), Cu(II) and Mg(II) complexes of gatifloxacin is reported. Ligand is itself prepared using o-phenylenediamine (OPD) and 3-acetyl coumarin. The structure of complexes has been investigated using some physiochemical and spectroscopic techniques. In vitro evaluation of these complexes was also carried out for antibacterial and antimicrobial activity. Some complexes exhibited promising anti-bacterial and antimicrobial activity compared to gatifloxacin drug.
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