非裔美国人和欧裔美国成年人胰岛素原与c肽比值作为β细胞功能的标志物

IF 14.8 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes Care Pub Date : 2023-12-01 DOI:10.2337/dc22-1763
Catharine A Couch, Francesca Piccinini, Lauren A Fowler, W Timothy Garvey, Barbara A Gower
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引用次数: 0

摘要

目的:本研究的主要目的是验证一种假设,即作为胰岛素原分泌指标的PI-to-CP比值,非裔美国成年人相对于无2型糖尿病的欧美成年人更高,并与β细胞功能指标相关。研究设计与方法:114名非裔美国人和欧裔美国人成年男女。通过2 h口服糖耐量试验测定葡萄糖、胰岛素、c肽和胰岛素原,得出β细胞对葡萄糖的反应指标。松田指数是用来衡量胰岛素敏感性的。计算β细胞反应各期胰岛素敏感性与β细胞反应的乘积处置指数(DI)。采用Pearson相关性研究pi - cp比值与β细胞反应各期的关系(basal, Φb;动态,Φd;静态的,Φ年代;total, Φtot),性格指数(DId, DIs, DItot)和胰岛素敏感性。采用多元线性回归分析评估种族、BMI和葡萄糖耐量状况对胰岛素敏感性调整前后pi - cp水平的独立贡献。结果:非裔美国参与者有较高的空腹和2小时pi - cp比率。空腹pi - cp比与Φb呈正相关,只有非裔美国人的空腹pi - cp比和2小时pi - cp比与DId和胰岛素敏感性呈负相关。结论:pi / cp比值可用于识别β细胞功能障碍和最终2型糖尿病风险最高的非裔美国人。
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Proinsulin-to-C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults.

Objective: The primary purpose of the current study was to test the hypothesis that the proinsulin-to-C-peptide (PI-to-CP) ratio, as an index of proinsulin secretion, would be higher and associated with indices of β-cell function in African American adults relative to European American adults without type 2 diabetes.

Research design and methods: Participants were 114 African American and European American adult men and women. A 2-h oral glucose tolerance test was conducted to measure glucose, insulin, C-peptide, and proinsulin and derive indices of β-cell response to glucose. The Matsuda index was calculated as a measure of insulin sensitivity. The disposition index (DI), the product of insulin sensitivity and β-cell response, was calculated for each phase of β-cell responsivity. Pearson correlations were used to investigate the relationship of the PI-to-CP ratio with each phase of β-cell response (basal, Φb; dynamic, Φd; static, Φs; total, Φtot), disposition indices (DId, DIs, DItot), and insulin sensitivity. Multiple linear regression analysis was used to evaluate independent contributions of race, BMI, and glucose tolerance status on PI-to-CP levels before and after adjustment for insulin sensitivity.

Results: African American participants had higher fasting and 2-h PI-to-CP ratios. The fasting PI-to-CP ratio was positively associated with Φb, and the fasting PI-to-CP ratio and 2-h PI-to-CP ratio were inversely associated with DId and insulin sensitivity only in African American participants.

Conclusions: The PI-to-CP ratio could be useful in identifying African American individuals at highest risk for β-cell dysfunction and ultimately type 2 diabetes.

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来源期刊
Diabetes Care
Diabetes Care 医学-内分泌学与代谢
CiteScore
27.80
自引率
4.90%
发文量
449
审稿时长
1 months
期刊介绍: The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.
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