多种阳性和阴性因素的相互作用决定了金黄色葡萄球菌对甲氧西林的耐药性。

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2022-06-15 DOI:10.1128/mmbr.00159-21
Bohdan L Bilyk, Viralkumar V Panchal, Mariana Tinajero-Trejo, Jamie K Hobbs, Simon J Foster
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引用次数: 11

摘要

对β-内酰胺类抗生素耐药的发展已使金黄色葡萄球菌成为全球范围内的临床负担。MRSA(耐甲氧西林金黄色葡萄球菌)通常被称为超级细菌。MRSA在β-内酰胺存在下的增殖能力归因于mecA的获得,mecA编码替代青霉素结合蛋白PBP2A,该蛋白对抗生素不敏感。大多数MRSA分离株表现出低水平的β-内酰胺耐药性,因此需要额外的基因调整才能产生高水平的耐药性。虽然已经确定了几个增强或需要高水平抗性的遗传因素,但这些因素如何在机制水平上相互作用仍然难以捉摸。在这里,我们讨论了抗性的发展,并评估了相关成分在调整生理以适应传入的mecA中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus.

The development of resistance to β-lactam antibiotics has made Staphylococcus aureus a clinical burden on a global scale. MRSA (methicillin-resistant S. aureus) is commonly known as a superbug. The ability of MRSA to proliferate in the presence of β-lactams is attributed to the acquisition of mecA, which encodes the alternative penicillin binding protein, PBP2A, which is insensitive to the antibiotics. Most MRSA isolates exhibit low-level β-lactam resistance, whereby additional genetic adjustments are required to develop high-level resistance. Although several genetic factors that potentiate or are required for high-level resistance have been identified, how these interact at the mechanistic level has remained elusive. Here, we discuss the development of resistance and assess the role of the associated components in tailoring physiology to accommodate incoming mecA.

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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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