巴基斯坦两种菌根伞菌的定性真菌化学分析和治疗潜力的外推。

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI:10.1615/IntJMedMushrooms.2023047505
Muniba Shafique, Abdul Rehman Niazi, Muhammad Imran, Muhammad Zaheer
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引用次数: 0

摘要

本研究旨在评价两种金刚鹦鹉的抗菌和驱虫潜力,即A. orsonii和A. glarea,并进行定性的真菌化学筛选。采用浸渍法在非极性溶剂(石油醚和氯仿)和极性溶剂(乙醇和蒸馏水)中制备粗提物。定性的真菌化学筛选显示存在多种次生代谢物,如萜类、黄酮类、单宁、生物碱、皂苷和心苷。采用琼脂孔扩散法对4株细菌和1株真菌进行抑菌试验。石油醚提取物对荧光假单胞菌的抑菌作用范围为4.86±0.088 mm ~ 34.83±0.166 mm,其中石油醚提取物对荧光假单胞菌的抑菌作用最大,而奥氏单胞菌浸渍蒸馏水对大肠杆菌的抑菌作用最小。对茄枯病菌的抑菌活性范围为14.5±0.288 ~ 24.76±0.145 mm,其中三氯甲烷提取物对茄枯病菌的抑菌活性最高,石油醚提取物对茄枯病菌的抑菌活性最低。以抗菌素和抗真菌片为对照品,部分粗提物的抑菌范围较对照品大。两种蘑菇不同浓度的乙醇提取物对弓形血螨的驱虫潜力进行了研究。所有粗提物均比标准奥克斯达唑有效。虫虫死亡电位范围为9.9±0.057 ~ 54.93±0.033 min,瘫痪时间范围为4.86±0.088 ~ 24.86±0.088 min。由此得出结论,这两种蘑菇都可以作为治疗性抗菌、抗真菌和驱虫药的潜在来源,用于制药工业生产药物和筛选次生代谢物。
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Extrapolating Qualitative Mycochemical Profiling and Therapeutic Potential of Two Mycorrhizal Amanita Species (Agaricomycetes) from Pakistan.

The present study was an attempt to evaluate the antimicrobial and anthelmintic potential of two Amanita species, i.e., A. orsonii and A. glarea, along with their qualitative mycochemical screening. Maceration technique was adopted to make crude extracts in non-polar (petroleum ether and chloroform) and polar (ethanol and distilled water) solvents. Qualitative mycochemical screening revealed the presence of a variety of secondary metabolites like terpenoids, flavonoids, tannins, alkaloids, saponins, and cardiac glycosides. Antimicrobial activities were carried out by using agar well diffusing method against four bacterial and one fungal strain. The antibacterial potential ranged between 4.86 ± 0.088 mm and 34.83 ± 0.166 mm with maximum inhibition zone exhibited by petroleum ether extract against Pseudomonas fluorescens and least potential by distilled water macerate of A. orsonii against the Escherichia coli. The antifungal activity ranged between 14.5 ± 0.288 and 24.76 ± 0.145 mm, with the highest potential provided by chloroform extract of A. orsonii and least capability put forward by A. glarea by petroleum ether extract against Fusarium solanii. Antibiotics and antimycotic discs were used as standard and some of the crude extracts showed bigger zone of inhibition as compared to standard. Different concentrations of ethanolic extracts of both mushrooms were subjected to anthelmintic potential against parasite Haemonchus contortus. All the crude extracts were more potent than standard oxfandazole used. Anthelmintic potential ranged between 9.9 ± 0.057 and 54.93 ± 0.033 minutes for death of parasite, while the paralyzed time ranged between 4.86 ± 0.088 and 24.86 ± 0.088 minutes. From the results obtained it was concluded that both mushrooms can be used as potential source of curative antibacterial, antifungal, and anthelmintic agents against several diseases that might be used in pharmaceutical industries for making medicines and to screen out secondary metabolites in future.

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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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