评估pd基大块金属玻璃生物相容性的体内临床前研究。

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2023-01-01 DOI:10.3233/BME-221392
Lukasz Witek, Vasudev Vivekanand Nayak, Ricardo Rodriguez Colon, Andrea Torroni, Marios D Demetriou, Paulo G Coelho
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引用次数: 0

摘要

背景:大块金属玻璃(BMG) Pd79Ag3.5P6Si9.5Ge2具有较高的断裂韧性,并且与大多数其他BMG不同,它可以适应屈服后应力。此外,由于其较大的惰性气体成分,它具有固有的耐腐蚀性,是牙科和骨科植入物的理想选择。目的:本研究旨在评价Pd79Ag3.5P6Si9.5Ge2在大型转译羊模型中的体内应用,以评估其作为内膜装置的功效。方法:采用快速淬火法制备12个直径为3mm的圆柱形棒状种植体。每只羊(n = 12)使用旋转器械在下颌骨区域进行一次截骨,填充Pd79Ag3.5P6Si9.5Ge2。6周和24周后,对这些动物实施安乐死,并整体收集样本进行组织形态学分析。通过骨与种植体接触(BIC)评估骨整合程度。结果:所有样本在6周和24周时均显示良好的BIC和纤维结缔组织层。6周时,在金属玻璃表面附近观察到骨和界面重塑,在愈合时间较晚的24周时观察到更高程度的骨组织。结论:合成的BMG由于其独特的韧性和强度组合,显示出作为常用钛合金替代品的潜力。
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An in vivo preclinical study assessing biocompatibility of Pd-based bulk metallic glass.

Background: The bulk metallic glass (BMG), Pd79Ag3.5P6Si9.5Ge2, has a high fracture toughness and has been found to accommodate post-yield stress, unlike most other BMG. Moreover, due to its greater noble gas composition it has a intrinsic corrosion resistance, ideal for dental and orthopedic implants.

Objective: This present study aimed to evaluate the in vivo application of Pd79Ag3.5P6Si9.5Ge2 in a large translational sheep model to assess its efficacy to be utilized as an endosteal device.

Methods: Twelve implants in the form of cylindrical rods (3 mm in diameter) were produced through rapid quenching. Each sheep (n = 12) received one osteotomy in the mandibular region using rotary instrumentation, which was filled with Pd79Ag3.5P6Si9.5Ge2. After 6- and 24-weeks the animals were euthanized, and samples collected en bloc to conduct histomorphometric analysis. The degree of osseointegration were assessed through bone-to-implant contact (BIC).

Results: All samples revealed favorable BIC along with with fibrous connective tissue layers at both 6- and 24-weeks. Bone along with interfacial remodeling was observed in proximity with the metallic glass surface at 6 weeks with higher degrees of bone organization being observed at the later healing time, 24 weeks.

Conclusions: The synthesized BMG, given its unique combination of toughness and strength, revealed potential to serve as an alternative to commonly used Ti alloys.

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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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