来自 Barringtonia macrocarpa 的异龙脑二萜衍生物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-09-16 DOI:10.1080/14786419.2023.2217467

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引用次数: 0

摘要

通过不同的色谱分离方法，从 Barringtonia macrocarpa 枝叶的 MeOH 残留物中获得了一种新的异杨烷二萜--barringisol（1）和两种新的异杨烷二萜葡萄糖苷--barringisosides A 和 B（2 和 3）。通过光谱方法（包括一维、二维核磁共振和 HR-ESI-QTOF-MS）确认了其结构特征。这是首次从巴林藤属植物中分离出异紫罗兰烷二萜衍生物。此外，还利用 SRB 检测法研究了 1-3 对三种人类癌细胞株（HepG2、LNCaP 和 MCF7）的体外细胞毒性。

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Isoryanodane diterpene derivatives from Barringtonia macrocarpa

From the MeOH residue of Barringtonia macrocarpa branches and leaves, one new isoryanodane diterpene, barringisol (1), and two new isoryanodane diterpene glucosides, barringisosides A and B (2 and 3), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from Barringtonia species. Moreover, the in vitro cytotoxicity of 1−3 on three human cancer cell lines (HepG2, LNCaP and MCF7) was also accessed using SRB assays.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.