香烟冷凝物对小鼠体内繁殖的影响

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-06-01 Epub Date: 2023-04-11 DOI:10.1017/S0967199423000072
Omid Banafshi, Mohammad Abdi, Vahideh Assadollahi, Ebrahim Mohammadi, Ebrahim Ghaderi, Mohammad Bagher Khadem Erfan, Mohammad Jafar Rezaei, Vida Aghamiri, Fardin Fathi
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引用次数: 0

摘要

吸烟会对包括生殖系统在内的各种身体组织产生危险的、有时甚至是不可逆的影响。我们进行了这项研究,以确定香烟烟气冷凝物(CSC)对小鼠生殖系统的体内影响。在这项体内实验研究中,32 只雌雄 NMRI 小鼠被分为四组。小鼠注射 CSC(CSC-1R3F)28 天。小鼠在最后一次注射后 1 天交配,并在 1 周内每天观察阴道塞是否存在,以追踪交配情况。我们对交配成功率、精子和卵细胞质量、妊娠结果、生育状况和体外受精(IVF)进行了评估。结果显示,注射了CSC的雌性小鼠交配成功率下降。CSC明显影响雄性小鼠的后代数量。与只注射 CSC 的雌性小鼠组相比,注射 CSC 的雄性小鼠的后代数量明显增加。研究结果表明,CSC 对雄性和雌性小鼠的形态参数均有负面影响。此外,雌性小鼠受CSC影响后,IVF成功率明显下降。结果表明,CSC会明显影响雌性小鼠的后代数量和受精成功率。
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Effects of cigarette smoke condensate on reproduction in mice in vivo.

Smoking has dangerous and sometimes irreversible effects on various body tissues, including the reproductive system. We conducted this research to determine the in vivo effects of cigarette smoke condensate (CSC) on reproduction in mice. In this experimental in vivo study, 32 male and female NMRI mice were divided into four groups. The mice were injected with CSC (CSC-1R3F) for 28 days. The mice were mated 1 day after the last injection and observed daily for 1 week for the presence of a vaginal plug to track mating. We evaluated mating success rate, and sperm and oocyte quality, pregnancy outcome, childbearing status, and in vitro fertilization (IVF). The results showed a decrease in successful mating in female mice that received the CSC injections. CSC significantly influenced the number of offspring born to males. When the CSC was injected into male mice, there was a significant increase in the number of offspring compared with the group in which only the females received CSC injections. According to the results, there was a negative effect of CSC on morphological parameters in male and female mice. Also, successful IVF after exposure to CSC was significantly decreased in the female mice treated group. The results indicated that CSC significantly affected the number of offspring and fecundity success in females.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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