肿瘤微环境在口腔癌变中的作用及表观遗传学对肿瘤微环境的影响:潜在意义。

Q4 Biochemistry, Genetics and Molecular Biology Critical Reviews in Oncogenesis Pub Date : 2022-01-01 DOI:10.1615/CritRevOncog.2022047088

Sagar Dholariya, Ragini D Singh, Madhuri Radadiya, Deepak Parchwani, Gaurav Sharma, Rashid Mir

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引用次数: 0

摘要

口腔癌已成为世界范围内的一个重大问题，特别是在发展中国家。最近的文献支持肿瘤微环境(tumor microenvironment, TME)成分的贡献以及TME细胞中发生的表观遗传变化对口腔癌发生和进展的影响。在这篇综述中，我们全面研究了TME在OC发展中的意义，以及目前对调节TME的表观遗传修饰的理解，以及它们对肿瘤特征的内聚影响和它们作为治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of the Tumor Microenvironment and the Influence of Epigenetics on the Tumor Microenvironment in Oral Carcinogenesis: Potential Implications.

Oral cancer has become a significant problem throughout the world, particularly in countries that are still developing. Recent literature supports the contribution of components of the tumor microenvironment (TME) and the effect of epigenetic changes happening in the cells of the TME on oral cancer development and progression. In this review, we comprehensively examine the significance of TME in the development of OC along with the current understanding of the epigenetic modifications that regulate the TME and their cohesive impact on tumor traits and their potential as therapeutic targets.

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来源期刊

Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

1.70

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0.00%

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期刊介绍： The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.

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