Ana Cecília Novaes de Oliveira Roldan, Luiz Carlos Cantanhede Fernandes Júnior, Carlos Eduardo Coral de Oliveira, Sandra Odebrecht Vargas Nunes
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引用次数: 1
摘要
目的:通过系统回顾和荟萃分析，探讨CACNA1C-rs1006737和ZNF804A-rs1344706基因多态性与精神分裂症(SCZ)和双相情感障碍(BD)患者认知表现的关系，为临床实践提供参考。方法:我们基于PICO模型和PRISMA，使用资格和排除标准检索网站数据库(PubMED、PsycINFO、Web of Science、EMBASE和Cochrane Library)，以捕获所有潜在的研究。结果:本系统综述纳入8篇文献(5篇涉及CACNA1C-rs1006737多态性，3篇涉及ZNF804A-rs1344706多态性)，共纳入5759名受试者(SCZ患者1751例，BD患者348例，对照组3626例，一级亲属34例)。结果表明，CACNA1C-rs1006737的合并效应(风险差RD = 0.08;95% CI 0.02-0.15)与严重精神障碍患者认知功能改变相关，但与ZNF804A-rs1344706多态性无关(RD = 0.19;95% ci 0.09-0.48。结论:本荟萃分析提供了CACNA1C-rs1006737多态性与严重精神障碍患者认知表现存在轻微关联的证据，表明与CACNA1C rs1006737风险变异相关的严重精神障碍患者认知功能障碍仅在与环境暴露相互作用时才会表达。本研究已在普洛斯彼罗注册，注册号为CRD42021246726。
Impact of ZNF804A rs1344706 or CACNA1C rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis.
Objectives: This systematic review and meta-analysis focussed on insights into the relationship between CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms and cognitive performance in schizophrenia (SCZ) spectrum and bipolar disorder (BD) and provide some contributions for clinical practice.
Methods: We searched the websites databases (PubMED, PsycINFO, Web of Science, EMBASE and Cochrane Library) using eligibility and exclusion criteria to capture all potential studies, based on PICO model and according to the PRISMA.
Results: Eight articles were included in this systematic review (five referring to CACNA1C-rs1006737 and three related to ZNF804A-rs1344706 polymorphisms), with a total of 5759 participants (1751 SCZ patients, 348 BD patients, 3626 controls and 34 first-degree relatives). The results demonstrated that the pooled effect of CACNA1C-rs1006737 (risk difference RD = 0.08; 95% CI 0.02-0.15) was associated with altered cognitive function in patients with severe mental disorders, but not ZNF804A-rs1344706 polymorphism (RD = 0.19; 95% CI 0.09-0.48.
Conclusion: The present meta-analysis provides evidence regarding slight association between CACNA1C-rs1006737 polymorphisms and cognitive performance in severe mental disorders, indicating that cognitive impairment in severe mental disorders associated with the CACNA1C rs1006737 risk variants could only be expressed when interacting with environmental exposures. This study is registered with PROSPERO, number CRD42021246726.
期刊介绍：
The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers.
The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.
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