肌肉减少症对胰腺癌患者预后的影响:一项系统综述和荟萃分析。

IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Scottish Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-07-14 DOI:10.1177/00369330231187655
Hui Gan, Jiarong Lan, Hongxia Bei, Guangxing Xu
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引用次数: 0

摘要

目的:总结胰腺癌患者骨骼肌质量和骨骼肌质量与总生存期和无复发生存期之间的关系。方法:使用Medline(通过PubMed)、Embase和Scopus数据库系统检索报告总生存期和无复发生存期的观察性研究。汇总效应量以风险比和95%置信区间报告。结果:共纳入34项研究。低骨骼肌指数(表明肌肉质量)与较差的总生存率相关(风险比:1.50;95%可信区间:1.34,1.67)和更低的无复发生存率(风险比:1.28,95%可信区间:1.15,1.43)。低骨骼肌衰减(表明肌肉质量)与较差的总生存率相关(风险比:1.32;95%置信区间:1.05,1.66)。骨骼肌衰减低和正常/高的患者无复发生存率相似(风险比:1.12,95%可信区间:0.89,1.40)。结论:骨骼肌质量低和肌肉质量差与长期生存率差有关。低骨骼肌指数,而不是低骨骼肌衰减,与不良的无复发生存相关。
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The impact of sarcopenia on prognosis of patients with pancreatic cancer: A systematic review and meta-analysis.

Objective: To summarize recent findings on the association of low skeletal muscle mass and muscle quality with overall survival and recurrence-free survival in patients with pancreatic cancer.

Methods: A systematic search was conducted using Medline (via PubMed), Embase and Scopus databases for observational studies reporting on the overall survival and recurrence-free survival. Pooled effect sizes were reported as hazards ratio along with 95% confidence intervals.

Results: A total of 34 studies were included. Low skeletal muscle index (indicating muscle mass) was associated with poor overall survival (hazards ratio: 1.50; 95% confidence interval: 1.34, 1.67) and lower recurrence-free survival (hazards ratio: 1.28, 95% confidence interval: 1.15, 1.43). Low skeletal muscle attenuation (indicating muscle quality) was associated with poor overall survival (hazards ratio: 1.32; 95% confidence interval: 1.05, 1.66). Recurrence-free survival was similar in patients with low and normal/high skeletal muscle attenuation (hazards ratio: 1.12, 95% confidence interval: 0.89, 1.40).

Conclusion: Both low skeletal muscle mass and poor muscle quality are associated with poor long-term survival. Low skeletal muscle index, but not low skeletal muscle attenuation, are associated with poor recurrence-free survival.

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来源期刊
Scottish Medical Journal
Scottish Medical Journal 医学-医学:内科
CiteScore
4.80
自引率
3.70%
发文量
42
审稿时长
>12 weeks
期刊介绍: A unique international information source for the latest news and issues concerning the Scottish medical community. Contributions are drawn from Scotland and its medical institutions, through an array of international authors. In addition to original papers, Scottish Medical Journal publishes commissioned educational review articles, case reports, historical articles, and sponsoring society abstracts.This journal is a member of the Committee on Publications Ethics (COPE).
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