Current Knowledge About the Impact of Maternal and Infant Nutrition on the Development of the Microbiota-Gut-Brain Axis.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2023-08-21 DOI:10.1146/annurev-nutr-061021-025355
Tomás Cerdó, Ana Nieto-Ruíz, José Antonio García-Santos, Anna Rodríguez-Pöhnlein, María García-Ricobaraza, Antonio Suárez, Mercedes G Bermúdez, Cristina Campoy
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引用次数: 2

Abstract

The prenatal and early postnatal periods are stages during which dynamic changes and the development of the brain and gut microbiota occur, and nutrition is one of the most important modifiable factors that influences this process. Given the bidirectional cross talk between the gut microbiota and the brain through the microbiota-gut-brain axis (MGBA), there is growing interest in evaluating the potential effects of nutritional interventions administered during these critical developmental windows on gut microbiota composition and function and their association with neurodevelopmental outcomes. We review recent preclinical and clinical evidence from animal studies and infant/child populations. Although further research is needed, growing evidence suggests that different functional nutrients affect the establishment and development of the microbiota-gut-brain axis and could have preventive and therapeutic use in the treatment of neuropsychiatric disorders. Therefore, more in-depth knowledge regarding the effect of nutrition on the MGBA during critical developmental windows may enable the prevention of later neurocognitive and behavioral disorders and allow the establishment of individualized nutrition-based programs that can be used from the prenatal to the early and middle stages of life.

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目前关于母婴营养对微生物-肠-脑轴发育影响的知识。
产前和产后早期是大脑和肠道微生物群发生动态变化和发育的阶段,营养是影响这一过程的最重要的可改变因素之一。考虑到肠道微生物群和大脑之间通过微生物-肠-脑轴(MGBA)的双向串音,在这些关键的发育窗口期进行营养干预对肠道微生物群组成和功能的潜在影响及其与神经发育结果的关联越来越受到关注。我们回顾了最近来自动物研究和婴儿/儿童人群的临床前和临床证据。虽然还需要进一步的研究,但越来越多的证据表明,不同的功能性营养素会影响微生物-肠道-脑轴的建立和发育,并可能在神经精神疾病的治疗中具有预防和治疗作用。因此,更深入地了解营养对关键发育窗口期MGBA的影响,可能有助于预防后来的神经认知和行为障碍,并允许建立个性化的基于营养的计划,可以从产前到生命的早期和中期阶段使用。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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