The role of lipids in cancer progression and metastasis.

IF 27.7 1区 生物学 Q1 CELL BIOLOGY Cell metabolism Pub Date : 2022-11-01 DOI:10.1016/j.cmet.2022.09.023
Miguel Martin-Perez, Uxue Urdiroz-Urricelqui, Claudia Bigas, Salvador Aznar Benitah
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引用次数: 46

Abstract

Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.

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脂质在癌症进展和转移中的作用。
脂质在体内具有重要的生物学功能(例如,提供能量储存,作为信号分子,作为膜的结构成分);然而,过量的脂质可以促进肿瘤的发生、定植和肿瘤细胞的转移能力。为了转移,肿瘤细胞经历了不同的阶段,需要脂质相关的代谢和结构适应。这些适应包括改变脂质膜组成以入侵其他生态位,克服细胞死亡机制,促进脂质分解代谢和合成代谢以达到能量和氧化应激保护的目的。癌细胞也利用脂质代谢来调节基质细胞和免疫细胞的活性,使其对治疗产生抵抗并促进复发。考虑到西方饮食中的高脂肪摄入量,这一切尤其令人担忧。因此,旨在降低脂质对癌细胞的可利用性或加剧其代谢脆弱性的代谢干预为预防癌症进展和治疗转移提供了有希望的治疗机会。
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来源期刊
Cell metabolism
Cell metabolism 生物-内分泌学与代谢
CiteScore
48.60
自引率
1.40%
发文量
173
审稿时长
2.5 months
期刊介绍: Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.
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