Thin-Film Transistor Platform for Electrophysiological and Electrochemical Characterization of Biological Cells

A. Eiler, Pierre-Marie Faure, J. Sugita, S. Ihida, D. Zhu, Y. Sakai, K. Fujiu, K. Komori, H. Toshiyoshi, A. Tixier-Mita
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引用次数: 2

Abstract

This paper presents a locally-addressable 2-dimensional arrayed transparent electrode platform with integrated Thin-Film Transistor (TFT) for electrophysiology. 2D electrical measurements on 28 parallel-connected lines selected from a 22,500 microelectrode array were successfully performed for heart cell investigation for the first time. Amperometry measurement was also demonstrated using transparent electrodes functionalized with Ag/AgCl by additive manufacturing. The applicability of this transparent TFT substrate platform to electrochemical sensors was confirmed by experiments. The platform offers a unique access to versatile lab-on-a-chip devices that integrate many measurement techniques on one chip (electrical, chemical and optical) for the study of large cell cultures, tissues or organoids.
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生物细胞电生理和电化学表征的薄膜晶体管平台
提出了一种集成薄膜晶体管(TFT)的局部可寻址二维阵列透明电生理电极平台。从22500个微电极阵列中选择28条平行连接的线进行二维电测量,首次成功用于心脏细胞研究。通过增材制造,还演示了使用Ag/AgCl功能化的透明电极进行安培测量。实验证实了该透明TFT基板平台在电化学传感器上的适用性。该平台为多功能芯片实验室设备提供了独特的访问途径,该设备在一个芯片上集成了许多测量技术(电气,化学和光学),用于研究大型细胞培养物,组织或类器官。
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