The labor of intestinal fence in inflammatory bowel disease

Abstract

The intestinal tract is summoned with many multifarious and arduous task like digestion and nutrient absorption. The host has to provide a serene coexistence with this divergent microbial community, as the gut lumen cherish an huge number of microorganisms. Appropriate detection and expulsion of pathogenic microorganisms is a way of avoidance along with prevention of an inordinate immune response against commensals.1–4 The intestinal mucosa is supplied with diverse specific and unspecific safeguarding mechanisms that unitedly build a obscure and effectual mucosal barrier, in order to thinder a injurious adhesion and encouragement of microorganisms.5,6 The symptoms of this disease are manifested as Diarrhoea, Fever and fatigue, Abdominal pain and cramping, Blood in your stool, reduced appetite and Unintended weight loss.