Molar pregnancy – case presentation of 23-year old pregnant women with partial molar pregnancy

E. Kovachev, G. Ingilizova, S. Anzhel, G. Yaneva, G. Nenkova
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Abstract

Molar pregnancy occurs 1-2 per 1000 pregnancies, resulting in improper fertilization. Partial mole is a result of fertilization of a haploid normal oocyte with two spermatozoa simultaneously, with the formation of a zygote with a triploid set of chromosomes. Only in around 25% of cases is a variant with euploid fetus (46XX/XY). Several factors determine the prognosis of the fetus in partial molar pregnancy, such as karyotype of the fetus, size of the area with hydropic degeneration of the placenta, rate of hydropic degeneration and manifestation of fetal anemia or other obstetric complications such as preeclampsia, thyrotoxicosis and vaginal bleeding. The authors present a clinical case of partial molar pregnancy with death fetus and classical clinical picture of the pregnant women with excessive hCG values, teca lutein cysts and vaginal bleeding. The available modalities for treatment are discussed, focused on vacuum curettage as the treatment of choice with lesser risk of complications and impact on the future fertility.
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磨牙妊娠:23岁孕妇部分磨牙妊娠1例
磨牙妊娠发生率为千分之1-2,导致受精不当。部分痣是单倍体正常卵母细胞与两个精子同时受精的结果,形成具有三倍体染色体的受精卵。只有大约25%的病例是整倍体胎儿(46XX/XY)的变体。有几个因素决定部分磨牙妊娠胎儿的预后,如胎儿的核型、胎盘积水变性区大小、积水变性率、胎儿贫血或其他产科并发症的表现,如子痫前期、甲状腺毒症和阴道出血。本文报告1例部分磨牙妊娠死胎及hCG值过高、黄体黄素囊肿、阴道出血孕妇的典型临床表现。讨论了可用的治疗方式,重点是真空刮除作为治疗的选择,并发症的风险较小,对未来的生育能力的影响。
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