Dieta isenta de glúten e risco de desfechos gestacionais desfavoráveis em mulheres com doença celíaca: revisão sistemática

Abstract

Aim

To review the published data on the association between maternal celiac disease and adverse pregnancy outcomes and its relationship to gluten‐free diet.

Sources

A systematic review of Biblioteca Virtual em Saúde (LILACS, IBECS, MEDLINE, SciELO, and Cochrane) and PubMed databases was performed. Cohort studies that compared the incidence of adverse pregnancy outcomes in women with treated and untreated celiac disease were included in the analysis. STROBE criteria was used to assess the internal validity of the studies.

Summary of the findings

Maternal untreated celiac disease was associated with premature births, low birthweight and small for gestational age. When celiac disease was treated, the risk of these outcomes was similar that found in people without celiac disease.

Conclusions

Untreated maternal celiac disease was associated with adverse pregnancy outcomes. Treatment with gluten‐free diet reduced significantly the risk of these outcomes, making the rate similar to that observed on women without celiac disease.