Impacto dos agentes antineoplásicos sobre os folículos ovarianos e importância das biotécnicas reprodutivas na preservação da fertilidade humana

Reprodu??o & Climatério Pub Date : 2015-05-01 DOI:10.1016/j.recli.2015.09.004

Denise Damasceno Guerreiro, Adeline de Andrade Carvalho, Laritza Ferreira Lima, Giovanna Quintino Rodrigues, José Ricardo de Figueiredo, Ana Paula Ribeiro Rodrigues

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引用次数: 1

Abstract

The preservation of fertility in young women of reproductive age has become a major challenge in medicine, since most cancer treatments can cause premature ovarian failure due to ovarian toxicity of chemotherapeutic agents. Based on this sensitivity it is necessary to revert or minimize damage to reproductive cells resulting from chemotherapy. It have become more frequent studies and researches for alternatives to preserve female fertility, and treatments that are more selective for cancer cells. Currently there are several options for preservation of fertility in women undergoing chemotherapy treatments.

This article aims to present an overview of the damage caused by chemotherapy ovarian function and possible options for preserving fertility in female cancer patients and prospects in oncofertilidade. A search on databases were searched for relevant articles: the National Library of Medicine (PubMed) and the Virtual Health Library. Articles published between 1967 and 2015 on chemotherapeutic agents and their damage on female fertility was held.

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抗肿瘤药物对卵泡的影响及生殖生物技术在保存人类生育能力中的重要性

由于化疗药物的卵巢毒性，大多数癌症治疗可导致卵巢早衰，因此保持育龄年轻女性的生育能力已成为医学上的主要挑战。基于这种敏感性，有必要恢复或尽量减少化疗对生殖细胞造成的损害。对于保留女性生育能力的替代方法以及对癌细胞更具选择性的治疗方法的研究和研究越来越频繁。目前，在接受化疗的妇女中，有几种保留生育能力的选择。本文旨在概述化疗对女性癌症患者卵巢功能的损害，以及保留生育能力的可能选择和不孕不育的前景。在数据库中搜索相关文章:国家医学图书馆(PubMed)和虚拟健康图书馆。1967年至2015年间发表的关于化疗药物及其对女性生育能力损害的文章被保留。

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