Batch Fabrication of Out-of-Plane, IC-Compatible, Nanoscale-Tip Silicon Neuroprobe Arrays

A. Goryu, A. Ikedo, K. Takei, K. Sawada, T. Kawano, M. Ishida
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引用次数: 1

Abstract

We developed a batch-fabrication of nanoscale-tip silicon microprobe arrays for use in multipoint nanoscale investigations of cell/neuron in-vivo/in-vitro. Sharpened tips, less than 100nm diameter, can be formed at the tips of out-of-plane three-dimensional silicon microprobe (length ≫10¿m) arrays, by silicon wet etching-based batch-process within only 1-3min, providing precisely controlled tip angles ranging from 15° to 50°. The penetration capability of the nanoscale-tip microprobes was demonstrated, using finite element modeling (FEM) simulations and penetration tests with a gelatin as tissue/cell.
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面外、集成电路兼容、纳米级尖端硅神经探针阵列的批量制造
我们开发了一种纳米级尖端硅微探针阵列,用于体内/体外细胞/神经元的多点纳米级研究。采用硅湿蚀刻成批工艺,可以在1-3min的时间内,在面外三维硅微探针(长度> 10¿m)阵列的尖端形成直径小于100nm的锐尖,尖端角度可精确控制在15°到50°之间。通过有限元模拟和以明胶为组织/细胞的渗透试验,验证了纳米探针的渗透能力。
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